Sign up to be notified about Rayaldee news.

Message frequency may vary. You may opt out at any time.
Terms of Use and Privacy Policy

Financial Support

OPKO Connect provides comprehensive support

OPKO Connect offers support for your office on behalf of your patients who have been prescribed Rayaldee® (calcifediol).

Benefits Investigation

OPKO Connect will verify the patient’s insurance coverage for Rayaldee, including identifying

• Prior authorization requirements
• Deductible, co-insurance, and out-of-pocket costs

Prior Authorization (PA) Assistance

OPKO Connect services are described in a circle: Benefits investigation, prior authorization support, appeals support, copay assistance programs, patient assistance programs, general support/assistance.

OPKO Connect will assist with any insurance-required PAs for Rayaldee by

• Completing and submitting insurer-specific PA forms
• Confirming receipt of submission by insurance and facilitating a timely review
• Providing status from insurance to patients and their healthcare provider’s office

Support for Appeals if the PA is Denied

OPKO Connect will

• Confirm the reason for the PA denial and provide options for appeals submission
• Supply a letter of medical necessity (LMN) template specific to Rayaldee
• Provide appeal status from insurance to patients and their healthcare provider’s office

Copay Assistance

Eligible, commercially insured patients can fill their Rayaldee prescription for $5 per month until the annual maximum limit is reached.

Copay card
* Eligible, commercially insured patients can fill their Rayaldee prescription for $5 per month.

Patient Assistance Program (PAP)

For patients without Rayaldee pharmacy insurance coverage, OPKO Connect has a patient assistance program offering free medication. Eligibility criteria apply and annual reenrollment is required.

Download the application for patient assistance.

PDF image of form
• English
• Spanish
• Mandarin
Copay card
* Eligible, commercially insured patients can fill their Rayaldee prescription for $5 per month.

To receive support for your patients, please complete a Rayaldee Service Request Form (SRF) and return to OPKO Connect.

• Fax 1-844-660-7083
• Email opkoconnect@rxallcare.com

OPKO Connect services are available

by phone at 1-844-414-6756
or by email opkoconnect@rxallcare.com
Monday through Friday, 8am to 8pm ET

PDF image of form

Download a letter of medical necessity.
PDF image of form

Download the Rayaldee Service Request Form.

Important Safety Information

• Hypercalcemia: Excessive administration of vitamin D compounds, including Rayaldee, can cause hypercalcemia and hypercalciuria. Severe hypercalcemia due to substantial overdosage of vitamin D and its metabolites may require emergency attention. Patients should be informed about the symptoms of elevated calcium.
• Digitalis toxicity: Potentiated by hypercalcemia of any cause. Monitor serum calcium and signs and symptoms of digitalis toxicity more frequently when initiating or adjusting the dose of Rayaldee.
• Adynamic Bone Disease: Monitor for abnormally low levels of intact parathyroid hormone (iPTH) levels when using Rayaldee, and adjust dose if needed.
• The most common adverse reactions (≥3% and more frequent than placebo) were anemia, nasopharyngitis, increased blood creatinine, dyspnea, cough, congestive heart failure and constipation.
• Care should be taken while dosing Rayaldee with cytochrome P450 inhibitors, thiazides, cholestyramine or drugs stimulating microsomal hydroxylation due to the potential for drug interactions.
• Serum calcium should be below 9.8 mg/dL before initiating treatment.
• Monitor serum calcium, phosphorus, 25-hydroxyvitamin D and iPTH 3 months after starting therapy or changing dose.

Please see Full Prescribing Information.

Indication and Limitations of Use

Rayaldee® (calcifediol) extended-release 30 mcg capsules is indicated for the treatment of secondary hyperparathyroidism in adults with stage 3 or 4 chronic kidney disease and serum total 25-hydroxyvitamin D levels less than 30 ng/mL. Rayaldee is not indicated in patients with stage 5 chronic kidney disease or end-stage renal disease on dialysis.

Important Safety Information

• Hypercalcemia: Excessive administration of vitamin D compounds, including Rayaldee, can cause hypercalcemia and hypercalciuria. Severe hypercalcemia due to substantial overdosage of vitamin D and its metabolites may require emergency attention. Patients should be informed about the symptoms of elevated calcium.
• Digitalis toxicity: Potentiated by hypercalcemia of any cause. Monitor serum calcium and signs and symptoms of digitalis toxicity more frequently when initiating or adjusting the dose of Rayaldee.
• Adynamic Bone Disease: Monitor for abnormally low levels of intact parathyroid hormone (iPTH) levels when using Rayaldee, and adjust dose if needed.
• The most common adverse reactions (≥3% and more frequent than placebo) were anemia, nasopharyngitis, increased blood creatinine, dyspnea, cough, congestive heart failure and constipation.
• Care should be taken while dosing Rayaldee with cytochrome P450 inhibitors, thiazides, cholestyramine or drugs stimulating microsomal hydroxylation due to the potential for drug interactions.
• Serum calcium should be below 9.8 mg/dL before initiating treatment.
• Monitor serum calcium, phosphorus, 25-hydroxyvitamin D and iPTH 3 months after starting therapy or changing dose.

Please see Full Prescribing Information.